Myoglobin (MYO)
| Description |
MYO protein (18.0kD) with His-tag, cultured in vitro |
| Applications |
Calibrator and quality control product |
| Catalog number |
K2916 |
| Source |
E. coli |
| Purity |
>90% as analysized by SDS-PAGE |
| Buffer |
1 x PBS，pH 7.4 |
| Storage instructions |
Store at 2 - 8°C (35.6 – 46.4°F) for up to 3 years. |
| Sequence |
MHHHHHHGLS DGEWQLVLNV WGKVEADIPG HGQEVLIRLF KGHPETLEKF DKFKHLKSED EMKASEDLKK HGATVLTALG GILKKKGHHE AEIKPLAQSH ATKHKIPVKY LEFISECIIQ VLQSKHPGDF GADAQGAMNK ALELFRKDMA SNYKELGFQG |
| SDS-PAGE |
 |
| Platform detection |
|
Clinical Significance
Myoglobin (MYO) is a small cytoplasmic oxygen-binding protein located in skeletal as well as the cardiac muscle. MYO is released extremely early into the serum, 1 h after the onset of myocardial injury, peaks at 4–12 h and returns to baseline values immediately.
MYO has a high sensitivity and a high negative predictive value for myocardial cell death. However, the major disadvantage of MYO is the lack of specificity to the cardiac tissue due to the presence of large amounts of MYO in the skeletal muscle. The levels of MYO can therefore not be used as a single diagnostic marker, but in conjunction with the troponins (CTnI) or CK-MB. Serum levels of MYO can be used to early rule out, rather than diagnose myocardial infarction.
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